New Cholesteryl Ester Transfer Protein from Indonesian Herbal Plants as Candidate Treatment of Cardiovascular Disease

BACKGROUND: There is a strong negative relationship between high-density lipoprotein cholesterol (HDL-C) and the risk of cardiovascular disease (CVD). Cholesterol ester transfer protein (CETP) glycoprotein transporter that transfers esters to very low-density (LDL-C). The CETP inhibitor new strategy against CVD because its ability increase HDL-C. Various Indonesian plants have not been optimally used, in silico phytochemical screening these showing potential as inhibitors still limited. AIM: This study for exploring phytochemicals treatments. METHODS: We screened 457 registered herbal database met Lipinski’s rule five. Their molecular structures were downloaded from PubChem database. three-dimensional dalcetrapib (the standard) obtained data bank (http://www.rcsb.org/pdb/) with 4EWS code ZINC ZINC03976476 code, respectively. CETP–dalcetrapib binding complexes validated 5 times using AutoDock Vina 1.1.2 software. Interactions molecularly docked same software visualized Pymol 1.8× RESULTS: Dalcetrapib had docking score −9.22 kcal/mol bound at Ser230 His232 residues. 11 lower scores than dalcetrapib, but only L-(+)-tartaric acid, chitranone, oxoxylopine could interact residue. These are commonly found Tamarindus indica, Plumbago zeylanica, Annona reticulata, CONCLUSION: L-(+)-Tartaric show silico.